Depression Research

A Swedish National Twin Study of Lifetime Major Depression.
Am J Psychiatry 163:109-114, January 2006.

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Depressive disorders and immunity: 20 years of progress and discovery.
Brain Behav Immun. 2007 May;21(4):374-83. Epub 2007 Mar 13.

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Effects of risperidone augmentation in patients with treatment-resistant depression: Results of open-label treatment followed by double-blind continuation.
Neuropsychopharmacology. 2006 Nov;31(11):2505-13. Epub 2006 Jun 7.

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Selective serotonin reuptake inhibitors and risk of suicide: a systematic review of observational studies.
CMAJ February 3, 2009; 180 (3).
A meta-analysis of 8 large-scale observational studies involving more than 200 000 patients with moderate or severe depression.

“…children and adolescents should be followed very closely because of the possibility of increased of risk suicidal thoughts and suicide. Paroxetine and venlafaxine may be better avoided based on the increasing evidence from randomized and observational studies that the risks might outweigh the benefits for most adolescents.”

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Descriptive epidemiology of major depression in Canada.

The lifetime prevalence of major depressive episode was 12.2%.

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A neurotrophic model for stress-related mood disorders.
Biol Psychiatry. 2006 Jun 15;59(12):1116-27. Epub 2006 Apr 21.

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Life events, first depression onset and the serotonin transporter gene.
The British Journal of Psychiatry (2006) 188: 210-215.

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Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: Relation to hypercortisolism and corticotropin-releasing hormone.
PNAS  January 4, 2000.

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Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications.
Biol Psychiatry. 2008 Sep 15;64(6):527-32. Epub 2008 Jun 24.

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